Cortical demyelination and diffuse white matter injury in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Cortical demyelination and diffuse white matter injury in multiple sclerosis.
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain the patient's clinical deficits. We thus analysed global brain pathology in multiple sclerosis, focusing on the normal-appearing white matter (NAWM) and the cortex. Autopsy tissue from 52 multiple sclerosis patients (acute, relapsing-remitting, primary and secondary progres...
متن کاملLack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis.
BACKGROUND Histopathologic studies have shown that subpial cortical demyelination is extensive in chronic multiple sclerosis (MS). OBJECTIVE To study whether subpial cortical demyelination in MS is associated with focal or diffuse white matter (WM) pathologic features on magnetic resonance imaging (MR imaging). DESIGN Comparison of postmortem MR imaging findings with histopathologic finding...
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BACKGROUND Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonanc...
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Sjogren-Larsson Syndrome (SLS) is an inherited autosomal recessive neurocutaneous disorder with congenital ichthyosis, spastic diplegia or quadriplegia and mental retardation. We report a case of Sjogren-Larsson Syndrome with clinical profile (mental retardation, ichthyosis, spastic diplegia) and MRI findings such as seen in multiple sclerosis (MS). So this rare syndrome can be another differen...
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299 Received February 12, 2014; revised and accepted November 13, 2014. Published online December 12, 2014; doi: 10.1620/tjem.234.299. Correspondence: Tadashi Matsuda, M.D., Center for Perinatal-Neonatal Medicine, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. e-mail: [email protected] Cerebral Ischemia or Intrauterine Inflammation Promotes Different...
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ژورنال
عنوان ژورنال: Brain
سال: 2005
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awh641